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Systemic Anti-Cancer Therapy Regimen Library

Home > LEU ALL BCR-ABL1+ - UKALL60+ with daSATinib > LEU - UKALL60+ with daSATinib Maintenance
This regimen is a component of LEU ALL BCR-ABL1+ - UKALL60+ with daSATinib

UKALL60+ with daSATinib Maintenance (LEU ALL BCR-ABL1+ - UKALL60+ with daSATinib)

Treatment Overview

Starts after recovery from Consolidation, with neutrophils greater than 0.75 x 109/L and platelets greater than 75 x 109/L.

Cycles 1 to 8 - 90 days

Cycle length:
90

daSATinib: Take continuously during treatment, an increase or reduction of dose is recommended based on individual patient response and tolerability.


mercaptOPURine:

  • 25 mg/m2 orally ONCE daily is the starting dose, see Additional details for recommended Dose adjustments to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Intrathecal metHOTREXATe: For Ommaya reservoir reduce dose to 6 mg intraventricularly.


Cycle details

Cycles 1 to 8 - 90 days

Medication Dose Route Days Max Duration
daSATinib * 70 mg Once daily oral administration 1 to 90
mercaptOPURine * 25 mg/m² Once daily oral administration 1 to 90
prEDNISone 60 mg/m² Once daily oral administration 1 to 5
vinCRISTine 1.4 mg/m² Cap dose per administration at: 2 mg intravenous 1 10 minutes
metHOTREXATe 12 mg flat dosing intrathecal injection 1

daSATinib: Take continuously during treatment, an increase or reduction of dose is recommended based on individual patient response and tolerability.


mercaptOPURine:

  • 25 mg/m2 orally ONCE daily is the starting dose, see Additional details for recommended Dose adjustments to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Intrathecal metHOTREXATe: For Ommaya reservoir reduce dose to 6 mg intraventricularly.


Full details

Cycles 1 to 8 - 90 days

Day: 1

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:
prEDNISone 60 mg/m² Once daily oral administration
Instructions:

Take in the morning with food.
vinCRISTine 1.4 mg/m² Cap dose per administration at: 2 mg intravenous 10 minutes
Instructions:
  • Diluted in a minibag.
  • FOR INTRAVENOUS USE ONLY – fatal if given by any other routes.
  • Warning vesicant—ensure vein is patent prior to administration, administer vesicant as per institutional policy and monitor for signs of extravasation throughout administration.
metHOTREXATe 12 mg flat dosing intrathecal injection
Instructions:
  • Adhere to local institution policy for intrathecal administration.
  • For Ommaya reservoir reduce dose to 6 mg intraventricularly.

Day: 2

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:
prEDNISone 60 mg/m² Once daily oral administration
Instructions:

Take in the morning with food.

Day: 3

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:
prEDNISone 60 mg/m² Once daily oral administration
Instructions:

Take in the morning with food.

Day: 4

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:
prEDNISone 60 mg/m² Once daily oral administration
Instructions:

Take in the morning with food.

Day: 5

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:
prEDNISone 60 mg/m² Once daily oral administration
Instructions:

Take in the morning with food.

Day: 6

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 7

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 8

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 9

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 10

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 11

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 12

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 13

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 14

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 15

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 16

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 17

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 18

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 19

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 20

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 21

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 22

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 23

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 24

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 25

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 26

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 27

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 28

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 29

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 30

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 31

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 32

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 33

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 34

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 35

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 36

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 37

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 38

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 39

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 40

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 41

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 42

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 43

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 44

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 45

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 46

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 47

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 48

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 49

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 50

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 51

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 52

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 53

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 54

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 55

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 56

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 57

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 58

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 59

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 60

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 61

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 62

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 63

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 64

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 65

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 66

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 67

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 68

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 69

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 70

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 71

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 72

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 73

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 74

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 75

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 76

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 77

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 78

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 79

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 80

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 81

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 82

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 83

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 84

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 85

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 86

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 87

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 88

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 89

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Day: 90

Medication Dose Route Max duration Details
daSATinib * 70 mg Once daily oral administration
Instructions:
  • Swallow whole, do not crush or chew with a large glass of water. Take at the same time each day.
  • Grapefruit or grapefruit juice may interact with this medicine. Discuss with your pharmacist.
  • Dose increase or reduction is recommended based on individual patient response and tolerability.
mercaptOPURine * 25 mg/m² Once daily oral administration
Instructions:
  • 25 mg/m2 ONCE daily is the starting dose, see Dose adjustments in Additional details.
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
Additional details:

Additional details

Section 1: Dose adjustments for mercaptOPURine

Supportive Care Factors

Factor Value
Antiviral prophylaxis for herpes virus: Routine antiviral prophylaxis recommended
Constipation risk: Variable
Diarrhoea risk: Variable
Emetogenicity: Minimal to low
Gastroprotection: Gastroprotection is recommended
Pneumocystis jirovecii pneumonia (PJP) prophylaxis: Routine antibiotic prophylaxis recommended

Antiviral prophylaxis for hepatitis B virus: Guidance is limited to high-risk anti-cancer medicines. Clinicians will need to assess individual patient risk for other anti-cancer medicines.


Constipation/Diarrhoea risk: daSATinib may cause diarrhoea and vinCRISTine may cause constipation. Monitor gastrointestinal symptoms.


Gastroprotection:

  • Gastroprotective agents such as proton pump inhibitors and H2 receptor antagonists are not recommended to be used with daSATinib because they may reduce exposure to daSATinib by increasing gastric pH. Consider using an antacid as an alternative.
  • Gastroprotective agents are only intended for short term use while patient is receiving corticosteroid treatment doses.

References

Bristol-Myers Squibb (NZ) Limited. Sprycel New Zealand Data Sheet 17 August 2022. https://www.medsafe.govt.nz/profs/datasheet/s/Spryceltab.pdf (Accessed 17 October 2022).

* The medicines, doses, combinations, and schedule in this treatment regimen have been carefully reviewed against international best practice guidelines by specialists in medical oncology around New Zealand and this advice has been accepted for publication by Te Aho o Te Kahu (the Cancer Control Agency). Sometimes medicines that are used in routine clinical practice have not been through a formal review process by the NZ Medicines Regulator Medsafe and are therefore considered unapproved or off-label. These medicines are legally able to be prescribed through sections 25 and 29 of the Medicines Act and by obtaining informed consent from patients. All treatment regimens listed on this website have been through robust peer review and are considered an accepted standard of care, whether prescribed through sections 25 or 29 or carrying formal Medsafe Approval.

s29: This symbol indicates that some formulations of the associated medicine are legally only able to be prescribed under section 29 of the Medicines Act. You can see which formulations are section 29 by hovering over the s29 symbol. You can access full medication details from the New Zealand Formulary by clicking on the medication name. Each clinician retains full responsibility for ensuring they have complied with all relevant obligations and requirements of section 29 including obtaining informed patient consent prior to prescribing the applicable medicine.